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个人信息:Personal Information
讲师 硕士生导师
教师拼音名称:lixiaoxi
电子邮箱:lixiaoxi@ujs.edu.cn
所在单位:医学院
办公地点:医学院2号楼1221室
职称:讲师
毕业院校:分子细胞科学卓越创新中心
硕士生导师
学科:临床检验诊断学
(1) Li Xiaoxi; Zhang Chenxiao*; Deng Minyao*; Jiang Yong; He Zhengjin; Qian Hui ; EFNB1 levels determine distinct drug response patterns guiding precision therapy for B-cell neoplasms, iScience, 2024, 27: 108667
Abstract: The multi-omics data has greatly improved the molecular diagnosis of B-cell neoplasms, but there is still a lack of predictive biomarkers to guide precision therapy. Here, we analyzed publicly available data and found that B-cell neoplasm cell lines with different levels of EFNB1 had distinctive drug response patterns of inhibitors targeting SRC/PI3K/AKT. Overexpression of EFNB1 promoted phosphorylation of key proteins in drug response, such as SRC and STMN1, conferring sensitivity to SRC inhibitor and cytotoxic drugs. EFNB1 phosphorylation signaling network was significantly associated with the prognosis of GCB-DLBCL patients. Moreover, EFNB1 levels were correlated with cell of origin (COO) scores, suggesting that EFNB1 is a quantitative indicator of cell differentiation. Ultimately, we proposed a model for the stratification of human B-cell malignancies and the implementation of targeted therapies based on EFNB1 levels. Our findings highlight that EFNB1 level is a promising biomarker for predicting drug response, COO and prognosis.