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个人信息:Personal Information
讲师 硕士生导师
教师拼音名称:lixiaoxi
电子邮箱:lixiaoxi@ujs.edu.cn
所在单位:医学院
办公地点:医学院2号楼1221室
职称:讲师
毕业院校:分子细胞科学卓越创新中心
硕士生导师
学科:临床检验诊断学
Hemann Lab
当前位置: M&T研究小组 >> 前沿进展 >> Hemann LabMichael T. Hemann
Associate Professor of Biology; Intramural Faculty, Koch Institute
Ludwig Center at MIT’s Koch Institute for Integrative Cancer Research
Koch Institute for Integrative Cancer Research At MIT
Michael T. Hemann - MIT Department of Biology
Professor Hemann uses high throughput genetics and tractable pre-clinical models to investigate basic mechanisms of cancer drug resistance.
LAB WEBSITE: Home | Hemann Lab (mit.edu)
Mike Hemann’s training and research has focused development of models of cancer evolution and therapeutic response. Michael T. Hemann, PhD | Hemann Lab (mit.edu)
As a post-doctoral fellow in Scott Lowe’s laboratory at Cold Spring Harbor Laboratory, he sought to develop tractable mouse models that could be used with the same ease as classic genetic model organisms to interrogate the genetics of cancer progression and treatment.
As a graduate student, he investigated mouse models of telomere dysfunction in Carol Greider’s laboratory.
The result of these efforts has been the development of diverse approaches that be directly applied to investigating mechanisms of tumor drug resistance.
Their consistent objective is the development of combination drug regimens that can subvert the evolution of drug resistance.
They have also been able to extend this work into the clinic in the context of treatment refractory malignancies.
The Hemann lab has pioneered the development of novel screening strategies to characterize the genetic determinants of drug action in relevant physiological settings.
A particular focus of this work is to develop strategies to sensitize tumors to front-line chemotherapy.
His group has made extensive use of mice as preclinical systems to examine therapeutic efficacy and have developed hematopoietic and solid tumor models that can effectively interrogate aspects of acquired and intrinsic drug resistance.
Research Summary:Many human cancers do not respond to chemotherapy, and often times those that initially respond eventually acquire drug resistance. Our lab uses high-throughput screening technology — combined with murine stem reconstitution and tumor transplantation systems — to investigate the genetic basis for this resistance. Our goal is to identify novel cancer drug targets, as well as strategies for tailoring existing cancer therapies to target the vulnerabilities associated with specific malignancies.
Research Interests:Using mouse models to combat cancers resistant to chemotherapy.
1. Microenvironmental Drug Resistance
2. In vivo screening for modulators of drug response
3. Examining single and combination mechanisms of drug action
Research Highlight
Unraveling Tumor Suppressor Networks with In Vivo RNAi: Cell Stem Cell
综述
Defining principles of combination drug mechanisms of action | PNAS
Drugs, Bugs, and Cancer: Fusobacterium nucleatum Promotes Chemoresistance in Colorectal Cancer: Cell
微环境Niche
DNA Damage-Mediated Induction of a Chemoresistant Niche: Cell Video
Context-specific roles for paracrine IL-6 in lymphomagenesis (cshlp.org)
Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy: Cell
异质性Heterogeneity与药效预测
A mammalian functional-genetic approach to characterizing cancer therapeutics - PubMed (nih.gov)
Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution: Cell
药物应答机制
遗传筛选-疾病发生与药物应答
独立前科研工作(hemann mt[Author - first]) - Search Results - PubMed (nih.gov)
博士Carol Greider’s laboratory
Telomere Length, Telomere-binding Proteins, and DNA Damage Signaling (cshlp.org)
博后Scott Lowe’s laboratory at Cold Spring Harbor Laboratory
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants | Nature
Suppression of tumorigenesis by the p53 target PUMA | PNAS
Topoisomerase levels determine chemotherapy response in vitro and in vivo | PNAS (过渡-通讯)
Oncogenes and senescence: breaking down in the fast lane (cshlp.org) (过渡-MIT)
The p53–Bcl-2 connection | Cell Death & Differentiation (nature.com) (综述)